Quantitation of myocardial 99mTc-HMDP uptake with new SPECT/CT cadmium zinc telluride (CZT) camera in patients with transthyretin-related cardiac amyloidosis: Ready for clinical use?
Quantitation of myocardial 99mTc-HMDP uptake with new SPECT/CT cadmium zinc telluride (CZT) camera in patients with transthyretin-related cardiac amyloidosis: Ready for clinical use?
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DOI：
10.1007/s12350-020-02274-2
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发表时间：
2020-07-26
影响因子：
2.4
通讯作者：
Manrique, Alain
中科院分区：
文献类型：
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作者：
Bellevre, Dimitri;Bailliez, Alban;Manrique, Alain
本研究的目的是探讨使用SUV和全身CZT SPECT-CT相机（DNM 670 CZT）评估疑似心脏ATTR患者心肌99 mTc-HMDP绝对摄取的可行性。方法对15例疑有心脏ATTR的患者（心包≥ 2）行常规99 mTc-HMDP平面显像和DNM 670 CZT胸部SPECT/CT检查。对照组15例，造影阴性（Percoli < 2）。在包含左心室的感兴趣心脏体积（VOI）中计算SUVmax（mg中心点L-1）和注射剂量百分比（%ID）。VOI也被放置在肺、右大胸和胸骨中。计算心肺SUVmax比值（AUC）。结果所有ATTR患者的心脏HMDP SUVmax（12.2 ± 3.7 mg中心点L-1）均高于对照组（3.5 ± 1.2，P <0.0001）。ATTR组的ID百分比、胸部摄取百分比和呼吸抑制百分比显著更高（1.1 +/- 0.3 vs 0.15 +/-0.8，P <0.0001; 1.5 +/- 0.3 vs 0.9 +/-0.3，P <0.0001; 9.7 +/- 3 vs 4.3 +/-2.2，P <0.0001）。两组之间的骨摄取无统计学差异。结论应用SPECT/CT CZT全身显像仪定量测定99 mTc-HMDP SUVmax在临床可疑心脏ATTR患者中的应用是可行的。
Background The aim of this study was to investigate the feasibility of assessing absolute myocardial 99mTc-HMDP uptake in patients with suspected cardiac ATTR using SUV with a whole-body CZT SPECT-CT camera (DNM670CZT). Methods Fifteen patients with suspected cardiac ATTR (Perugini >= 2) underwent a conventional 99mTc-HMDP planar imaging and a thoracic SPECT/CT using a DNM 670CZT. A control group consisted of 15 patients with negative scintigraphy (Perugini < 2). SUVmax (mg center dot L-1) and percentage of injected dose (%ID) were calculated in a cardiac volume of interest (VOI) encompassing the left ventricle. VOIs were also placed in the lung, the right pectoris major, and the sternum. A heart-to-lung SUVmax ratio (HLR) was calculated. Results All ATTR patients demonstrated an increased cardiac HMDP SUVmax (12.2 +/- 3.7 mg center dot L-1) vs controls (3.5 +/- 1.2,P < .0001). Percentage of ID, pectoral uptake and HLR were significantly higher in the ATTR group (1.1 +/- 0.3 vs 0.15 +/- 0.8,P < .0001; 1.5 +/- 0.3 vs 0.9 +/- 0.3,P < .0001; 9.7 +/- 3 vs 4.3 +/- 2.2,P < .0001). Bone uptake was not statistically different between the two groups. Conclusion This study demonstrated the feasibility of quantitative 99mTc-HMDP SUVmax measurement using a whole-body SPECT/CT CZT camera in patients with suspected cardiac ATTR.