Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?
Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?
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DOI：
10.1245/s10434-018-07151-4
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发表时间：
2019-04-01
影响因子：
3.7
通讯作者：
Heerdt, Alexandra
中科院分区：
文献类型：
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作者：
Downs-Canner, Stephanie;Zabor, Emily C.;Heerdt, Alexandra
尽管来自随机试验的数据支持70岁T1、雌激素受体阳性（ER+）肿瘤患者接受保乳治疗（BCT）时省略放射治疗（RT），但RT的使用仍然很高。我们回顾了我们的机构经验，以确定局部复发或合并症的危险因素是否影响使用。方法从前瞻性维护的数据库中筛选2010-2012年70岁T1、ER+、人表皮生长因子受体2阴性（HER2-）肿瘤行BCT的女性。使用Suemoto指数计算十年估计死亡率。临床病理特征和接受RT的死亡风险的关系进行了检查。结果共发现323例患者327例癌症。中位年龄75岁，中位肿瘤大小1cm，临床均为淋巴结阴性；53.7%的患者接受了放疗。随着年龄的增长，放疗的使用率下降(70-74岁为73.6%；75-79岁为49.5%；80-84岁为33.3%；85岁为10.7%
BackgroundDespite data from randomized trials supporting omission of radiation therapy (RT) for women70years of age with T1, estrogen receptor-positive (ER+) tumors undergoing breast-conserving therapy (BCT), RT usage remains high. We reviewed our institutional experience to determine if risk factors for local recurrence or comorbidities influenced use.MethodsWomen70years of age with T1, ER+, human epidermal growth factor receptor2-negative (HER2-) tumors undergoing BCT in 2010-2012 were identified from a prospectively maintained database. Ten-year estimated mortality was calculated using the Suemoto index. The associations of clinicopathological features and mortality risk on receipt of RT were examined.ResultsOverall, 323 patients with 327 cancers were identified. Median age was 75years, median tumor size was 1cm, and all were clinically node negative; 53.7% of patients received RT. RT usage decreased with age (73.6%, age 70-74years; 49.5%, age 75-79years; 33.3%, age 80-84years; 10.7%,85years; p