Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root
Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root
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DOI：
10.1126/science.1160158
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发表时间：
2008-10-24
期刊：
影响因子：
56.9
通讯作者：
Beeckman, Tom
中科院分区：
文献类型：
--
作者：
De Smet, Ive;Vassileva, Valya;Beeckman, Tom
在多细胞生物的发育过程中，器官发生和模式形成依赖于形成性分裂来指定和维持干细胞库。在高等植物中，这些活动对于形成最终的根结构是必不可少的，因为根顶端分生组织的功能和侧根的从头形成完全依赖于它。我们使用转录谱对经历侧根起始的分选的周细胞进行鉴定，像拟南芥的激酶ACR4一样，在促进周膜中的形成性细胞分裂和限制这些分裂的数量方面都是关键因素，器官形成已经开始。在根尖分生组织中，ACR 4通过控制柱细胞谱系中的细胞增殖活性而显示出类似的作用。因此，ACR4的功能揭示了在主根尖分生组织和侧根发生过程中形成细胞分裂控制的共同机制。
During the development of multicellular organisms, organogenesis and pattern formation depend on formative divisions to specify and maintain pools of stem cells. In higher plants, these activities are essential to shape the final root architecture because the functioning of root apical meristems and the de novo formation of lateral roots entirely rely on it. We used transcript profiling on sorted pericycle cells undergoing lateral root initiation to identify the receptor-like kinase ACR4 of Arabidopsis as a key factor both in promoting formative cell divisions in the pericycle and in constraining the number of these divisions once organogenesis has been started. In the root tip meristem, ACR4 shows a similar action by controlling cell proliferation activity in the columella cell lineage. Thus, ACR4 function reveals a common mechanism of formative cell division control in the main root tip meristem and during lateral root initiation.