Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus
Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus
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DOI：
10.1053/j.gastro.2021.06.056
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发表时间：
2021-09-21
期刊：
影响因子：
29.4
通讯作者：
Ng, Siew C.
中科院分区：
文献类型：
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作者：
Yang, Keli;Niu, Junkun;Ng, Siew C.
背景与目的：肥胖和2型糖尿病（T2 DM）与肠道细菌组成的变化有关，但对病毒群落（病毒组）在疾病发展中的作用知之甚少。本研究的目的是描述伴有或不伴有T2 DM的肥胖受试者的肠道病毒组改变。方法：128名肥胖受试者（体重指数≥ 28 kg/m2）和101名瘦对照者（体重指数≥ 18.5，
BACKGROUND & AIMS: Obesity and type 2 diabetes melli -tus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM. METHODS: There were 128 obese subjects (body mass index >= 28 kg/m(2)) and 101 lean controls (body mass index >= 18.5 and