Drug Targets in Neurotrophin Signaling in the Central and Peripheral Nervous System.
Drug Targets in Neurotrophin Signaling in the Central and Peripheral Nervous System.
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DOI：
10.1007/s12035-018-0885-3
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发表时间：
2018-08
影响因子：
5.1
通讯作者：
Tyagi P
中科院分区：
文献类型：
--
作者：
Kashyap MP;Roberts C;Waseem M;Tyagi P
神经营养因子是一类在中枢和周围神经系统神经元生长、存活和分化调控中起重要作用的蛋白。神经营养因子在早期发育、生长、维持和神经系统发育过程中的可塑性中起着重要作用，但最近的研究结果也表明，它们在神经和非神经组织的正常生理过程中都起着复杂的作用。因此，认识到神经营养因子的表达不足是很重要的，这是导致一些神经和精神疾病/障碍的衰弱特征的主要因素。另一方面，众所周知，神经营养因子的过度表达在慢性疼痛和传入敏化的发病机制、下尿路症状(LUTS)/疾病和骨关节炎等潜在疾病中起着关键作用。高亲和力和低亲和力受体的冗余受体系统的存在解释了神经营养因子在神经元和非神经元组织中以空间和时间方式产生的多种，通常是拮抗作用。此外，由于脊髓损伤和糖尿病等疾病引起的膀胱功能障碍的研究发现，膀胱中这些神经营养因子的水平以及感觉传入神经元的水平发生了变化，这进一步为治疗靶点开辟了新的途径。在这篇综述中，我们将讨论关键神经营养因子的特征和作用，以及它们在正常和病变情况下在中枢和周围神经系统中的作用。
Neurotrophins are a family of proteins that play an important role in the regulation of the growth, survival, and differentiation of neurons in the central and peripheral nervous system. Neurotrophins were earlier characterized by their role in early development, growth, maintenance, and the plasticity of the nervous system during development, but recent findings also indicate their complex role during normal physiology in both neuronal and non-neuronal tissues. Therefore, it is important to recognize a deficiency in the expression of neurotrophins, a major factor driving the debilitating features of several neurologic and psychiatric diseases/disorders. On the other hand, overexpression of neurotrophins is well known to play a critical role in pathogenesis of chronic pain and afferent sensitization, underlying conditions such as lower urinary tract symptoms (LUTS)/disorders and osteoarthritis. The existence of a redundant receptor system of high-and low-affinity receptors accounts for the diverse, often antagonistic, effects of neurotrophins in neurons and non-neuronal tissues in a spatial and temporal manner. In addition, studies looking at bladder dysfunction because of conditions such as spinal cord injury and diabetes mellitus have found alterations in the levels of these neurotrophins in the bladder, as well as in sensory afferent neurons, which further opens a new avenue for therapeutic targets. In this review, we will discuss the characteristics and roles of key neurotrophins and their involvement in the central and periphery nervous system in both normal and diseased conditions.
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影响因子：
4.6
作者：
Chen AI;Zang K;Masliah E;Reichardt LF
通讯作者：
Reichardt LF
影响因子：
5.3
作者：
Anastasia, Agustin;Barker, Phillip A.;Hempstead, Barbara L.
通讯作者：
Hempstead, Barbara L.
影响因子：
64.8
作者：
BARRES, BA;RAFF, MC;BARDE, YA
通讯作者：
BARDE, YA
DOI：
10.1002/neu.480251107
发表时间：
1994-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BARBACID, M
通讯作者：
BARBACID, M
影响因子：
3.8
作者：
Belanger, Patrice;Butler, Paul;Zorbas, Mark
通讯作者：
Zorbas, Mark