Perceptual and neural response to affective tactile texture stimulation in adults with autism spectrum disorders.
Perceptual and neural response to affective tactile texture stimulation in adults with autism spectrum disorders.
复制标题
DOI：
10.1002/aur.1224
复制
发表时间：
2012-08
期刊：
影响因子：
4.7
通讯作者：
Essick, Gregory K.
中科院分区：
文献类型：
--
作者：
Cascio, Carissa J.;Moana-Filho, Estephan J.;Guest, Steve;Nebel, Mary Beth;Weisner, Jonathan;Baranek, Grace T.;Essick, Gregory K.
自闭症谱系障碍（ASD）与感觉敏感性和对感觉刺激的情感反应的差异有关，其神经基础仍然很大程度上未知。我们利用心理物理学和功能磁共振成像 (fMRI) 来研究自闭症谱系障碍成人样本和对照组对三种纹理表面的体感刺激的反应，这些表面涵盖了一系列粗糙度和愉悦度。虽然两组对粗糙度和愉悦度的心理物理学评分基本相似，但自闭症谱系障碍组对令人愉悦和不愉快的纹理的平均评分比对照组更极端。此外，他们对中性纹理的评分比对照组变化更大，这表明他们在评估情感模糊的刺激时不太一致。各组之间响应于这些纹理的刺激而产生的脑血氧水平依赖性（BOLD）信号的变化有很大差异，与对照组相比，自闭症谱系障碍组的反应减弱，特别是对于令人愉快和中性的纹理。对于最令人不快的纹理，自闭症谱系障碍组在情感体感处理区域（例如后扣带皮层和岛叶）表现出比对照组更大的 BOLD 反应。根据自闭症诊断访谈修订版 (ADI-R) 的测量，岛叶对不愉快纹理的反应幅度与社交障碍呈正相关。这些结果表明，患有自闭症谱系障碍的人往往对愉快和中性的刺激反应减弱，而对不愉快的刺激反应过度，这可能导致与触摸相关的社会奖赏减少，持续的社交退缩和异常的社会发展。
Autism spectrum disorders (ASD) are associated with differences in sensory sensitivity and affective response to sensory stimuli, the neural basis of which is still largely unknown. We used psychophysics and functional magnetic resonance imaging (fMRI) to investigate responses to somatosensory stimulation with three textured surfaces that spanned a range of roughness and pleasantness in a sample of adults with ASD and a control group. While psychophysical ratings of roughness and pleasantness were largely similar across the two groups, the ASD group gave pleasant and unpleasant textures more extreme average ratings than did controls. In addition, their ratings for a neutral texture were more variable than controls, indicating they are less consistent in evaluating a stimulus that is affectively ambiguous. Changes in brain blood oxygenation level-dependent (BOLD) signal in response to stimulation with these textures differed substantially between the groups, with the ASD group exhibiting diminished responses compared to the control group, particularly for pleasant and neutral textures. For the most unpleasant texture, the ASD group exhibited greater BOLD response than controls in affective somatosensory processing areas such as the posterior cingulate cortex and the insula. The amplitude of response in the insula in response to the unpleasant texture was positively correlated with social impairment as measured by the Autism Diagnostic Interview-Revised (ADI-R). These results suggest that people with ASD tend to show diminished response to pleasant and neutral stimuli, and exaggerated limbic responses to unpleasant stimuli, which may contribute to diminished social reward associated with touch, perpetuating social withdrawal, and aberrant social development.
登录
查看更多内容
影响因子：
3.9
作者：
Cascio, Carissa;McGlone, Francis;Essick, Gregory
通讯作者：
Essick, Gregory
影响因子：
1.8
作者：
Guest, Steve;Essick, Greg;McGlone, Francis
通讯作者：
McGlone, Francis
影响因子：
5.7
作者：
Diedrichsen, J;Shadmehr, R
通讯作者：
Shadmehr, R
影响因子：
2.5
作者：
Downar, J;Crawley, AP;Davis, KD
通讯作者：
Davis, KD
影响因子：
1.5
作者：
Gillott, Alinda;Standen, P. J.
通讯作者：
Standen, P. J.