Thermogenic action of progesterone in the rat.
Thermogenic action of progesterone in the rat.
复制标题
黄体酮在大鼠中的产热作用。
作者：
M. E. Freeman;J. Crissman;G. Louw;R. Butcher;E. Inskeep
Progesterone has been shown to be thermogenic in a variety of species. The present studies investigated the role of the pituitary and thyroid glands in the thermogenic response to exogenous progesterone in 254 adult female rats. In intact rats, subcutaneous injections of 0.1 or 0.5 mg of progesterone daily for 14 days were ineffective in increasing rectal temperatures, whereas injections of 1.0, 2.0, 5.0 or 10.0 mg progesterone daily for 14 days increased rectal temperature by 0.3, 0.4, 0.4 and 0.5 C, respectively (p <0.05). Exogenous progesterone (5.0 mg daily) increased the rectal temperature of ovariectomized rats by 0.3 C (p <0.05). On the other hand, the rectal temperature of hypophysectomized rats was not increased by administration of progesterone. Thyroid acinar cell height was increased significantly from 7.4 to 9.3 μ by daily administration of 5.0 mg of progesterone to intact rats. Injection of 2-thiouracil (17.5 mg daily) lowered rectal temperature and blocked the thermogenic response to exogen...
