Involvement of blockade of leukotriene B4 action in anti-pruritic effects of emedastine in mice
Involvement of blockade of leukotriene B4 action in anti-pruritic effects of emedastine in mice
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DOI：
10.1016/s0014-2999(00)00637-3
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发表时间：
2000-10-06
影响因子：
5
通讯作者：
Kuraishi, Y
中科院分区：
文献类型：
--
作者：
Andoh, T;Kuraishi, Y
在小鼠中研究了富马酸依美斯汀的抗肠炎活性。依美斯汀（0.03-0.3 mg/kg）可抑制皮内注射组胺（100 nmol/部位）诱导的抓挠。依美斯汀（0.03-0.3 mg/kg）也可抑制P物质（100 nmol/部位）和白三烯B-4（0.03 nmol/部位）诱导的痉挛，但不能抑制5-羟色胺（100 nmol/部位）诱导的痉挛。皮内注射P物质可增加皮肤中白三烯B-4的浓度，而依美斯汀对其无影响。这些结果表明，依美斯汀对P物质诱导的瘙痒相关反应的抑制是通过阻断白三烯B-4作用介导的。抗白三烯B-4作用以及抗组胺作用可能有助于依美斯汀的抗炎症作用。(C)2000 Elsevier Science B. V.保留所有权利。
The anti-pruritic activity of emedastine difumarate was studied in mice. Emedastine (0.03-0.3 mg/kg) inhibited scratching induced by intradermal injection of histamine (100 nmol/site). Scratching induced by substance P (100 nmol/site) and leukotriene B-4 (0.03 nmol/site), but not by serotonin (100 nmol/site), was also suppressed by emedastine (0.03-0.3 mg/kg). Intradermal injection of substance P increased the cutaneous concentration of leukotriene B-4, which was not affected by emedastine. These results suggest that the inhibition by emedastine of substance P-induced itch-associated response is mediated by the blockade of leukotriene B-4 action. Anti-leukotriene B-4 action, as well as the anti-histamine action, may contribute to the anti-pruritic effects of emedastine. (C) 2000 Elsevier Science B.V. All rights reserved.