Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.
Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.
复制标题
人可变重链基因的多态性显示与恒定重链基因的连锁。
DOI：
10.1073/pnas.81.24.7840
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发表时间：
1984
影响因子：
11.1
通讯作者：
Cavalli-Sforza,LL
中科院分区：
文献类型：
--
作者：
Johnson,MJ;Natali,AM;Cann,HM;Honjo,T;Cavalli-Sforza,LL
本研究用免疫球蛋白可变重链区(Ig VH)探针检测了限制性片段长度多态(RFLP)，并分析了这些多态在家系中的遗传。用LOD(对数优势比)分析VHII基因簇内以及VHII基因与Ig CH基因之间的连锁关系。此外，VHII基因的位置被确定与另一个与CH基因紧密连锁和着丝粒的多态位点D14S1。分析了CH和VH簇基因之间的遗传关联。这些RFLP代表了具有遗传特征的VH区域的多态性，希望它们将有助于疾病相关性的研究以及进一步了解人类免疫球蛋白重链基因的遗传学。
In this study, restriction fragment length polymorphisms (RFLPs) were identified with an immunoglobulin variable heavy chain region (Ig VH) probe and the inheritance of the polymorphisms was analyzed in families. Linkage within the VHII gene cluster and between the VHII and Ig CH genes was investigated by lod (logarithm of odds) score analysis. In addition, the position of the VHII genes was determined in relation to another polymorphic locus--D14S1, which is tightly linked and centromeric to the CH genes. Genetic associations between genes in the CH and VH clusters were analyzed. These RFLPs represent genetically characterized VH region polymorphisms and it is hoped that they will facilitate the study of disease correlations as well as further the understanding of the genetics of the immunoglobulin heavy chain genes in humans.