Prevention of Type II diabetes in subjects with impaired glucose tolerance:: the Diabetes Prevention Study (DPS) in Finland -: Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
Prevention of Type II diabetes in subjects with impaired glucose tolerance:: the Diabetes Prevention Study (DPS) in Finland -: Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
复制标题
DOI：
10.1007/s001250051229
复制
发表时间：
1999-07-01
期刊：
影响因子：
8.2
通讯作者：
Tuomilehto, J
中科院分区：
文献类型：
--
作者：
Eriksson, J;Lindström, J;Tuomilehto, J
目的/假设。糖尿病预防研究的目的是评估强化饮食-运动方案在预防或延迟糖耐量受损受试者的II型（非胰岛素依赖型）糖尿病方面的疗效，评估干预方案对心血管危险因素的影响，并评估糖耐量受损患者进展为糖尿病的决定因素。共有523名超重受试者，通过两次口服葡萄糖耐量试验确定为葡萄糖耐量受损，随机分为对照组或干预组。对照组受试者在试验开始时接受了关于预防糖尿病所需的生活方式改变和年度随访的一般信息。干预对象在第一年与营养学家进行了七次会议，此后每3个月进行一次访问，旨在减少体重，饱和脂肪的摄入量和增加膳食纤维的摄入量。干预对象也被单独指导，以增加他们的身体活动。在第一年，前212名研究受试者的体重减轻为4.7 +/- 5.5 kg，干预组和对照组分别为0.9 +/- 4.1 kg（p < 0.001）。干预组的血糖浓度（空腹：5.9 +/- 0.7 vs 6.4 +/- 0.8 mmol/l，p < 0.001; 2小时7.8 +/- 1.8 vs 8.5 +/- 2.3 mmol/l，p < 0.05）在干预第一年后显著降低。干预组的血压、血脂和人体测量指标也有良好的变化。中期结果显示生活方式干预计划的成效和可行性。
Aims/hypothesis. The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiovascular risk factors and to assess the determinants for the progression to diabetes in persons with impaired glucose tolerance.Methods. A total of 523 overweight subjects with impaired glucose tolerance ascertained by two oral glucose tolerance tests were randomised to either a control or intervention group. The control subjects received general information at the start of the trial about the lifestyle changes necessary to prevent diabetes and about annual follow-up visits. The intervention subjects had seven sessions with a nutritionist during the first year and a visit every 3 months thereafter aimed at reducing weight, the intake of saturated fat and increasing the intake of dietary fibre. Intervention subjects were also guided individually to increase their physical activity.Results. During the first year, weight loss in the first 212 study subjects was 4.7 +/- 5.5 vs 0.9 +/- 4.1 kg in the intervention and control group, respectively (p < 0.001). The plasma glucose concentrations (fasting: 5.9 +/- 0.7 vs 6.4 +/- 0.8 mmol/l, p < 0.001; and 2-h 7.8 +/- 1.8 vs 8.5 +/- 2.3 mmol/l, p < 0.05) were significantly lower in the intervention group after the first year of intervention. Favourable changes were also found in blood pressure, serum lipids and anthropometric indices in the intervention group.Conclusion/interpretation. The interim results show the efficacy and feasibility of the lifestyle intervention programme.