VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells
VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells
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DOI：
10.1016/j.febslet.2007.08.063
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发表时间：
2007-10-02
期刊：
影响因子：
3.5
通讯作者：
Song, Yao-Hua
中科院分区：
文献类型：
--
作者：
Bai, Xiaowen;Sadat, Sanga;Song, Yao-Hua
已知心肌梗死后c-kit（+）细胞增加。心脏c-kit+细胞的确切来源仍有待确定。我们询问脂肪组织是否可能是c-kit+细胞的潜在来源。我们的数据显示，在无血清和缺氧条件下生长的新生心肌细胞的条件培养基中，脂肪组织来源的干细胞中c-kit（+）细胞的数量增加。我们还发现VEGF受体Flk-1通过ERK介导的途径参与c-kit的上调。(c)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit+ cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit+ cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.