Protection and measurement in radiation therapy.
Protection and measurement in radiation therapy.
复制标题
DOI：
10.1097/hp.0000000000000241
复制
发表时间：
2015-02
期刊：
影响因子：
2.2
通讯作者：
S. Sutlief
中科院分区：
文献类型：
--
作者：
S. Sutlief
在放射治疗中，与涉及放射的大多数其他应用不同，其目的是向患病组织递送高剂量的放射，受到放射对健康组织的影响的限制。关于患者照射，合理、优化和限制的辐射防护框架是放射治疗处方过程的直接部分。工作人员和公众的照射量通常远低于职业最大允许照射量。然而，在放射治疗中出现的许多其他问题属于辐射防护的范畴。经过历史回顾，本文讨论了放射治疗中的几个当代和新出现的问题，包括胎儿剂量，继发性恶性肿瘤和植入式器械的剂量，所有这些都涉及预期治疗体积之外的准确剂量评估。其他问题包括质量和安全性，基于分子的疾病评估和治疗，以及其他新的治疗策略。文件最后讨论了最佳做法与监管监督之间的相互作用。
In radiation therapy, unlike most other applications involving radiation, the intention is to deliver high doses of radiation to diseased tissue, constrained by the effects of radiation to healthy tissue. With regard to patient exposure, the radiation protection framework of justification, optimization, and limitation is a direct part of the prescription process of radiation therapy. Staff and public exposures are typically far below occupational maximum permissible exposures. However, a number of other issues arise in radiation therapy that fall into the category of radiation protection. After an historical review, this paper discusses several contemporary and emerging concerns within radiation therapy, including fetal dose, secondary malignancies, and dose to implantable devices, all of which involve accurate dose assessment outside the intended treatment volume. Other concerns include quality and safety, molecularly based disease assessment and treatment, and other novel treatment strategies. The paper ends with a discussion of the interplay between best practices and regulatory oversight.