Transmission of live, attenuated mumps virus to the human placenta.
Transmission of live, attenuated mumps virus to the human placenta.
复制标题
将活的减毒腮腺炎病毒传播至人类胎盘。
DOI：
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发表时间：
1974
影响因子：
158.5
通讯作者：
J. W. Geme
中科院分区：
文献类型：
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作者：
T. Yamauchi;C. Wilson;J. W. Geme
45名年龄在16岁至35岁之间的妇女，计划进行治疗性流产，筛查原发性腮腺炎病毒感染的易感性。通过腮腺炎病毒皮肤试验阴性和在皮肤试验时和7至10天后血清中不存在腮腺炎病毒中和抗体来确定敏感性。五名妇女，三个敏感和两个免疫，接受活的，减毒腮腺炎病毒疫苗终止妊娠前7至10天的羊膜腔内输注高渗盐水。从三名血清阴性妇女中的两名胎盘中回收了腮腺炎病毒，但从任何接种疫苗的胎儿组织中均未分离出病毒。青春期后女性应谨慎使用腮腺炎减毒活疫苗。（《新英格兰医学杂志》290：710-712，1974）
Abstract Forty-five women between the ages of 16 and 35 years, scheduled for therapeutic abortions, were screened for susceptibility to primary mumps-virus infection. Susceptibility was established by a negative mumps-virus skin test and the absence of mumps-virus neutralizing antibody in the serum at the time of skin testing and seven to 10 days later. Five women, three susceptible and two immune, received live, attenuated mumps-virus vaccine seven to 10 days before termination of pregnancy by the intra-amniotic infusion of hypertonic saline. Mumps virus was recovered from the placentas of two of the three seronegative women, but virus was not isolated from the fetal tissues of any of those vaccinated. Live, attenuated mumps-virus vaccine should be used with caution in the post-pubertal female. (N Engl J Med 290:710–712, 1974)