In-depth proteomics to define the cell surface and secretome of ovarian cancer cells and processes of protein shedding.
In-depth proteomics to define the cell surface and secretome of ovarian cancer cells and processes of protein shedding.
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DOI：
10.1158/0008-5472.can-08-3087
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发表时间：
2009-02-01
期刊：
影响因子：
11.2
通讯作者：
Hanash SM
中科院分区：
文献类型：
--
作者：
Faça VM;Hanash SM
目前的蛋白质组学技术允许对细胞和亚细胞蛋白质组进行大量深入的分析，如卵巢癌细胞的蛋白质组学图谱所示。这种深入的分析阐明了细胞表面表达的蛋白质和释放到细胞外环境中的蛋白质，揭示了细胞黏附蛋白胞外结构域的广泛脱落和一个高度动态的蛋白质分泌过程。已确定的蛋白质组为卵巢癌的成像和治疗提供了丰富的潜在循环标志物和靶点。
Current proteomics technologies allow substantial depth of analysis of cellular and subcellular proteomes as shown in the proteomic profiling of ovarian cancer cells. This in-depth analysis has elucidated the repertoire of proteins expressed on the cell surface and proteins released into the extracellular milieu, uncovering extensive shedding of extracellular domains of cell adhesion proteins and a highly dynamic protein secretion process. The protein sets identified provide a rich resource of potential circulating markers and targets for imaging and therapeutics for ovarian cancer.