Identification of enzymatic activities which process protein bound mono(ADP-ribose).
Identification of enzymatic activities which process protein bound mono(ADP-ribose).
复制标题
鉴定处理蛋白质结合单（ADP-核糖）的酶活性。
DOI：
10.1016/0006-291x(85)90582-0
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
Jacobson,MK
中科院分区：
文献类型：
--
作者：
Smith,KP;Benjamin,RC;Moss,J;Jacobson,MK
已在培养的小鼠细胞提取物中鉴定了酶活性，其催化去除在精氨酸处与蛋白质连接的完整单（ADP-核糖基）残基。还鉴定了依次去除AMP和核糖5-磷酸的活性。这些结果表明，单（ADP-核糖基化）的蛋白质是一个可逆的翻译后修饰。
Enzymatic activities have been identified in extracts of cultured mouse cells which catalyze the removal of intact mono(ADP-ribosyl) residues linked to proteins at arginine. Activities that sequentially remove AMP and ribose 5-phosphate have also been identified. These results suggest that mono(ADP-ribosylation) of proteins is a reversible post translational modification.