Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
复制标题
在没有糖尿病或高血压的 HIV 感染患者中，蛋白尿和白蛋白尿均与内皮功能障碍无关。
DOI：
10.1093/infdis/jir668
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dubé,MichaelP
中科院分区：
文献类型：
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作者：
Gupta,SamirK;Shen,Changyu;Mather,KierenJ;Agarwal,Rajiv;Dubé,MichaelP
目前尚不清楚系统性内皮功能障碍是否是人类免疫缺陷病毒（HIV）感染者肾病和心血管疾病（CVD）之间相关性的基础。在123名无糖尿病或高血压病史的HIV感染者（58名接受抗逆转录病毒治疗[ART]，65名未接受ART）中评价了点尿蛋白与肌酐比值、点尿白蛋白与肌酐比值、肌酐清除率、估计肾小球滤过率和肱动脉血流介导的扩张（FMD）。建模为连续变量或分类变量的肾脏标志物均与FMD无关。与预期相反，内皮功能障碍可能不是HIV肾病和CVD之间的联系。
It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV.