Inner Ear Damage and Passage through the round Window Membrane of Pseudomonas Aeruginosa Exotoxin a in a Chinchilla Model
Inner Ear Damage and Passage through the round Window Membrane of Pseudomonas Aeruginosa Exotoxin a in a Chinchilla Model
复制标题
龙猫模型中内耳损伤和铜绿假单胞菌外毒素 a 穿过圆窗膜
DOI：
10.1177/000348949210100511
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Bagger
中科院分区：
文献类型：
--
作者：
L. Lundman;T. Harada;P. Santi;S. Juhn;T. Morizono;D. Bagger
By the use of computer-assisted morphometric analysis of the organ of Corti and/or measurements of action potential threshold changes, inner ear changes in chinchillas were evaluated 4 weeks after application on the round window membrane of a Pseudomonas aeruginosa exotoxin A solution. Severe inner ear damage was detected after application of 50 ng (5 μL at a concentration of 10 μg/mL) exotoxin A, whereas application of 5 ng exotoxin did not cause measurable inner ear damage. Perilymph concentrations of exotoxin A were measured with an enzyme-linked immunosorbent assay 1.5 to 19 hours after 50 ng, 0.5 μg, or 5 μg of exotoxin A was applied on the round window membrane. Only the highest concentration produced measurable levels of exotoxin in the inner ear fluids. It is concluded that exotoxin A present on the round window membrane of the chinchilla has the ability to penetrate into the inner ear and cause irreversible inner ear changes.
抗原诱导的中耳炎中圆窗膜对人血清白蛋白的通透性。
影响因子：
2.5
作者：
Hamaguchi,Y;Morizono,T;Juhn,SK
通讯作者：
Juhn,SK
DOI：
10.1001/archotol.1988.01860230041019
发表时间：
1988
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
--
作者：
Goycoolea,MV;Muchow,D;Martinez,GC;Aguila,PB;Goycoolea,HG;Goycoolea,CV;Schachern,P;Knight,W
通讯作者：
Knight,W
DOI：
10.1001/archotol.1982.00790520010004
发表时间：
1982
期刊：
Archives of otolaryngology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Morizono,T;Sikora,MA
通讯作者：
Sikora,MA