Identification of S6K2 as a centrosome-located kinase.
Identification of S6K2 as a centrosome-located kinase.
复制标题
将 S6K2 鉴定为位于中心体的激酶。
DOI：
10.1016/j.febslet.2007.07.047
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发表时间：
2007
期刊：
影响因子：
3.5
通讯作者：
Lee-Fruman,KayK
中科院分区：
文献类型：
--
作者：
Rossi,Rossella;Pester,JohnM;McDowell,Mitch;Soza,Samuela;Montecucco,Alessandra;Lee-Fruman,KayK
Ribosomal S6 kinase 2 (S6K2) acts downstream of the mammalian target of rapamycin (mTOR). Here, we show that some S6K2 localize at the centrosome throughout the cell cycle. S6K2 is found in the pericentriolar area of the centrosome. S6K2 centrosomal localization is unaffected by serum withdrawal or treatment with rapamycin, wortmannin, U0126, or phorbol-12-myristate-13-acetate (PMA). Unlike S6K2, S6 kinase 1 (S6K1) does not localize at the centrosome, suggesting the two kinases may also have nonoverlapping functions. Our data suggest that centrosomal S6K2 may have a role in the phosphoinositide-3-kinase (PI3K)/Akt/mTOR signaling pathway that has also been detected in the centrosome.
