EFFECT OF MECHANICAL STIMULATION ON CELL-PROLIFERATION IN MOUSE EPIDERMIS AND ON GROWTH-REGULATION BY ENDOGENOUS FACTORS (CHALONES)
EFFECT OF MECHANICAL STIMULATION ON CELL-PROLIFERATION IN MOUSE EPIDERMIS AND ON GROWTH-REGULATION BY ENDOGENOUS FACTORS (CHALONES)
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DOI：
10.1111/j.1365-2184.1976.tb01295.x
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
MARKS, F
中科院分区：
文献类型：
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作者：
BERTSCH, S;CSONTOS, K;MARKS, F
通过皮肤按摩或去除角质层对小鼠背部皮肤的机械刺激导致DNA标记和有丝分裂活性的相互可比的增加。只有在受伤后，如去除角质层，增生发展。这种现象称为增生性转化，其特征在于表皮G1抑素反应性的短暂消除。有一些迹象表明，对热不稳定因子的敏感性，可能是表皮G2抑素，不受影响。皮肤按摩既不干扰对表皮G1抑素的反应性，也不诱导增生性转化。小鼠尾部表皮显示功能性增生，并对G1抑素有反应。为了解释这些观察结果，我们假设表皮干细胞群是由G1-chalone敏感和G1-chalone不敏感的细胞组成的异质性。
Mechanical stimulation of dorsal mouse skin by skin massage or removal of the horny layer results in a mutually comparable increase in DNA-labeling and mitotic activity. Only after injury, such as removal of the horny layer, does hyperplasia develop. This phenomenon, called hyperplastic transformation, is characterized by a transient abolition of the epidermal G1 chalone responsiveness. There is some indication that the susceptibility to a heat labile factor, probably the epidermal G2 chalone, is not affected. Skin massage neither interferes with the responsiveness to epiderman G1 chalone nor induces hyperplastic transformation. Mouse tail epidermis shows a functional hyperplasia and responds to the G1 chalone. To explain these observations, it is assumed that the epidermal stem cell population is heterogeneous consisting of G1 chalone-sensitive and G1 chalone-insensitive cells.