Translational relevance of fear conditioning in rodent models of mild traumatic brain injury.
Translational relevance of fear conditioning in rodent models of mild traumatic brain injury.
复制标题
轻度创伤性脑损伤啮齿动物模型中恐惧调节的转化相关性。
DOI：
10.1016/j.neubiorev.2021.04.037
复制
发表时间：
2021
影响因子：
8.2
通讯作者：
Browne,CarolineA
中科院分区：
文献类型：
--
作者：
Kostelnik,Claire;Lucki,Irwin;Choi,KwangH;Browne,CarolineA
轻度创伤性脑损伤（mTBI）增加了军人患创伤后应激障碍（PTSD）的风险。利用翻译相关的动物模型对于建立一个平台来描述在mTBI后数月至数年内出现的临床PTSD常见的神经行为缺陷是必要的。需要这样的平台来促进新疗法的临床前开发。首先，这篇小型综述概述了军人mTBI后PTSD的发病率。其次，评估了临床前研究中与mTBI结合使用的恐惧条件反射范式的翻译相关性。接下来，本综述解决了当前临床前文献中的一个重要空白；虽然在其他研究领域已经对恐惧的孵化进行了研究，但关于mTBI后线索和情境恐惧记忆随时间增强的研究相对较少。与mTBI相结合的恐惧范式的孵化被提出作为一种新的行为方法来推进这一关键领域的研究。最后，本综述讨论了mTBI后恐惧记忆改变的潜在神经生物学基础。
Mild traumatic brain injury (mTBI) increases the risk of posttraumatic stress disorder (PTSD) in military populations. Utilizing translationally relevant animal models is imperative for establishing a platform to delineate neurobehavioral deficits common to clinical PTSD that emerge in the months to years following mTBI. Such platforms are required to facilitate preclinical development of novel therapeutics. First, this mini review provides an overview of the incidence of PTSD following mTBI in military service members. Secondly, the translational relevance of fear conditioning paradigms used in conjunction with mTBI in preclinical studies is evaluated. Next, this review addresses an important gap in the current preclinical literature; while incubation of fear has been studied in other areas of research, there are relatively few studies pertaining to the enhancement of cued and contextual fear memory over time following mTBI. Incubation of fear paradigms in conjunction with mTBI are proposed as a novel behavioral approach to advance this critical area of research. Lastly, this review discusses potential neurobiological substrates implicated in altered fear memory post mTBI.