An overview of TCDD half-life in mammals and its correlation to body weight
An overview of TCDD half-life in mammals and its correlation to body weight
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DOI：
10.1016/s0045-6535(00)00442-2
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发表时间：
2001-05-01
期刊：
影响因子：
8.8
通讯作者：
di Domenico, A
中科院分区：
文献类型：
--
作者：
Miniero, R;De Felip, E;di Domenico, A
TCDD 在生物体中半衰期的主要决定因素是亲脂性、代谢和肝结合位点。此外，半衰期似乎在经验上与生物体体重相关。在本文中，通过对从文献中选择的半衰期测量和体重数据进行回归分析来评估这种相关性。特别考虑了对实验室哺乳动物和人类半衰期数据的单次暴露研究。分析结果似乎非常重要，可能是由于所考虑的生物体中物质的稳定性和通常缓慢的代谢。除体重以外的因素对半衰期的影响似乎并未显着影响回归线周围的数据分散。不能排除剂量依赖性排泄的潜在影响，因为毒代动力学研究通常是在高暴露剂量下进行的。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Major determinants of TCDD half-life in organisms are lipophylicity, metabolism, and hepatic binding sites. In addition, half-life seems to be empirically correlated to organism body weight. In this paper, this correlation is evaluated by a regression analysis of half-life measures and body weight data selected from the literature. Single exposure studies on laboratory mammals and human half-life data were specifically taken in consideration. The analysis outcome appears to be highly significant probably owing tb the stability and generally slow metabolism of the substance in the organisms considered. The effect on half-life of factors other than body weight does not seem to influence significantly data dispersion around the regression line. The potential effects of a dose-dependent excretion cannot be excluded as toxicokinetic studies have been usually carried out at high exposure doses. (C) 2001 Elsevier Science Ltd. All rights reserved.