PROJECTIONS FROM THE PREVERTEBRAL AND MAJOR PELVIC GANGLIA TO THE ILEUM AND LARGE-INTESTINE OF THE MALE-RAT
PROJECTIONS FROM THE PREVERTEBRAL AND MAJOR PELVIC GANGLIA TO THE ILEUM AND LARGE-INTESTINE OF THE MALE-RAT
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DOI：
10.1016/0165-1838(94)90171-6
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发表时间：
1994-11-01
期刊：
影响因子：
--
通讯作者：
KEAST, JR
中科院分区：
文献类型：
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作者：
LUCKENSMEYER, GB;KEAST, JR
肠的交感神经支配来自椎前和盆神经节，并且在不同程度上来自位于椎旁神经节、内脏神经和肠系膜间神经中的神经元。在这项研究中，我们将逆行示踪剂注射到回肠壁和大肠的几个区域，以确定从每个神经节和神经供应这些区域的神经元的比例。回肠的交感神经供应主要来自内脏神经和椎旁神经节T9-T11（SPL）和腹腔-肠系膜神经节复合体（CG/SMG）中的神经元，少量供应来自近端肠系膜间神经（IMN）。投射到近端结肠的神经元的分布是非常相似的，虽然一些标记的神经元被发现在整个长度的IMN，也在肠系膜下神经节（IMG）。中结肠主要由IMN和IMG供应，尽管该区域接受来自所研究的所有神经节和神经的神经支配，包括骨盆大神经节（MPG）。位于IMN远端三分之二的神经元和更多的尾部结构从远端结肠标记。远端结肠是肠中唯一接受来自MPG的相对较大的神经支配的区域，在IMN、IMG和MPG中的每一个中具有大约三分之一的标记神经元。这些研究还比较了两种逆行示踪剂，固蓝和荧光金。荧光金被发现特异性地标记投射到注射的肠的每个区域的神经元。然而，当注射到中结肠时，Fast Blue标记的神经元投射到该区域以及荧光金研究表明投射到其他区域的许多神经元;因此，Fast Blue应谨慎使用。
The sympathetic innervation of the gut arises from the prevertebral and pelvic ganglia, and to a variable extent, from neurons located in the paravertebral ganglia, the splanchnic and intermesenteric nerves. In this study we have injected retrograde tracers into the wall of the ileum and several regions of the large intestine to determine the proportion of neurons supplying these regions from each of the ganglia and nerves. The sympathetic supply to the ileum arises primarily from neurons in the splanchnic nerves and the paravertebral ganglia T9-T11 (SPL) and the coeliaco-mesenteric ganglion complex (CG/SMG), with a small supply from the proximal intermesenteric nerves (IMN). The distribution of neurons projecting to the proximal colon is very similar, although some labelled neurons are found throughout the length of the IMN and also in the inferior mesenteric ganglion (IMG). The middle colon is primarily supplied by the IMN and the IMG, although this region receives innervation from all the ganglia and nerves investigated, including the major pelvic ganglia (MPG). Neurons located in the distal two-thirds of the IMN and more caudal structures were labelled from the distal colon. The distal colon is the only region of gut to receive a relatively large innervation from the MPG, with approximately one third of labelled neurons in each of the IMN, IMG and the MPG, These studies also compared two retrograde tracers, Fast Blue and Fluorogold. Fluorogold was found specifically to label neurons projecting to each region of intestine injected. However, when injected into the middle colon, Fast Blue labelled neurons that project to this region as well as many neurons that Fluorogold studies indicate project to other regions; Fast Blue should therefore be used only with caution.