Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors
Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors
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DOI：
10.1002/jmri.24895
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发表时间：
2015-11-01
影响因子：
4.4
通讯作者：
Honda, Hiroshi
中科院分区：
文献类型：
--
作者：
Togao, Osamu;Hiwatashi, Akio;Honda, Hiroshi
目的评价基于平行透射法的酰胺质子转移(APT)脑肿瘤成像的重复性。材料与方法13例脑肿瘤患者，其中4例为低级别胶质瘤，3例为多形性胶质母细胞瘤，5例为脑膜瘤，1例为恶性淋巴瘤。APT成像采用双通道并行传输方案，饱和时间为2秒，B-1幅度为2 T，成像采用驱动平衡重聚焦的二维快速自旋回波序列。在从-6到+6ppm的25个频率偏移处获得Z谱(步长0.5ppm)。用B-0图进行逐点B-0校正。每名患者在不同的日子分两次进行扫描-再扫描重复性测试。两次会议之间的间隔为4.83.5天。放置感兴趣区(ROI)以包括每个病例的整个肿瘤。计算每个阶段整个肿瘤直方图APT信号的平均值和90%的值。用线性回归分析、组内相关系数(ICC)和Bland-Altman图评价APT信号在两次治疗期间和治疗期间的重复性。结果两次治疗前后肿瘤ROI的APT信号均值和90%值具有很好的一致性，线性回归分析的R-2分别为0.91和0.96，ICC分别为0.95和0.97。J·马根。雷森。成像2015；42：1346-1353。
PurposeTo evaluate the reproducibility of amide proton transfer (APT) imaging of brain tumors using a parallel transmission-based technique.Materials and MethodsThirteen patients with brain tumors (four low-grade gliomas, three glioblastoma multiforme, five meningiomas, and one malignant lymphoma) were included in the study. APT imaging was conducted at 3T using a 2-channel parallel transmission scheme with a saturation time of 2 seconds and B-1 amplitude of 2 T. A 2D fast spin-echo sequence with driven-equilibrium refocusing was used for imaging. Z-spectra were obtained at 25 frequency offsets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B-0 correction was performed with a B-0 map. A scan-rescan reproducibility test was performed in two sessions on separate days for each patient. The interval between the two sessions was 4.83.5 days. Regions-of-interest (ROIs) were placed to include the whole tumor for each case. A mean and 90-percentile value of APT signal for the whole tumor histogram was calculated for each session. The between-session and within-session reproducibility was evaluated using linear regression analysis, intraclass correlation coefficient (ICC), and a Bland-Altman plot.ResultsThe mean and 90-percentile values of the APT signal for whole tumor ROI showed excellent agreements between the two sessions, with R-2 of 0.91 and 0.96 in the linear regression analysis and ICC of 0.95 and 0.97, respectively.ConclusionParallel transmission-based APT imaging of brain tumors showed good reproducibility. J. Magn. Reson. Imaging 2015;42:1346-1353.