Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency.
Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency.
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DOI：
10.1016/s2222-1808(13)60052-3
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Joseph, B.
中科院分区：
文献类型：
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作者：
Baby Joseph, Baby Joseph;Jini, D.;Joseph, B.
糖尿病是发达国家和发展中国家最常见的疾病之一，该疾病在世界大部分地区迅速增加。据估计，多达三分之一的糖尿病患者使用某种形式的补充和替代药物。一种因其抗糖尿病特性而受到最多关注的植物是苦瓜，Momordica charantia (M. charantia)，通常被称为苦瓜，karela和苦瓜。它的果实也被用于治疗亚洲、南美、印度和东非土著居民的糖尿病和相关疾病。大量的临床前研究已经通过各种假设的机制证明了沙兰支原体的抗糖尿病和降糖作用。然而，人类受试者的临床试验数据有限，而且由于研究设计不良和统计效力低而存在缺陷。本文就其抗糖尿病活性、植物化学和药理学方面的报道进行综述，并呼吁开展更好设计的临床试验，进一步阐明其对糖尿病的治疗作用。
Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. One plant that has received the most attention for its anti-diabetic properties is bitter melon, Momordica charantia (M. charantia), commonly referred to as bitter gourd, karela and balsam pear. Its fruit is also used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented in the anti-diabetic and hypoglycaemic effects of M. charantia through various postulated mechanisms. However, clinical trial data with human subjects are limited and flawed by poor study design and low statistical power. The present review is an attempt to highlight the antidiabetic activity as well as phytochemical and pharmacological reports on M. charantia and calls for better-designed clinical trials to further elucidate its possible therapeutic effects on diabetes.