The armadillo as an animal model and reservoir host for Mycobacterium leprae
The armadillo as an animal model and reservoir host for Mycobacterium leprae
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DOI：
10.1016/j.clindermatol.2014.07.001
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发表时间：
2015-01-01
影响因子：
2.7
通讯作者：
Truman, Richard W.
中科院分区：
文献类型：
--
作者：
Balamayooran, Gayathriy;Pena, Maria;Truman, Richard W.
除人类外，螳螂是麻风分枝杆菌唯一已知的自然宿主。它们是麻风体内繁殖的宿主，是研究麻风发病机制和翻译研究的模型。螳螂在免疫上是完好无损的。它们表现出对麻风的组织病理学反应的全部Ridley-Joping谱，并独特地表现出广泛的神经参与，密切地概括了人类麻风。此外，已知在一些地区自由放养的螳螂存在自然发生的麻风病感染，并与大量新病例报告有关。我们回顾了螳螂作为麻风病模型和人类感染宿主的作用。由爱思唯尔公司出版。
Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection. Published by Elsevier Inc.