Predictors of functional capacity in colorectal cancer patients
Predictors of functional capacity in colorectal cancer patients
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结直肠癌患者功能能力的预测因素
DOI：
10.1007/s00520-015-2639-3
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发表时间：
2015
影响因子：
3.1
通讯作者：
T. Akman
中科院分区：
文献类型：
--
作者：
M. Tomruk;D. Karadibak;T. Yavuzşen;T. Akman
目的本研究的目的是确定功能能力的预测因素，并探讨功能能力，性能状态，疲劳，生活质量，焦虑和抑郁之间的关系，在大肠癌（CRC）patient.Methods42例诊断为II-III期CRC根据肿瘤，淋巴结，转移（TNM）分类纳入研究。分别使用六分钟步行测试（6 MWT）中的六分钟步行距离（6 MWD）、东部肿瘤协作组体力状态（ECOG-PS）、简明疲劳量表（BFI）、癌症治疗功能评估-结直肠（FACT-C）和医院焦虑和抑郁量表（HADS）评估CRC患者的功能能力、体力状态、疲劳、生活质量、焦虑和抑郁。结果6分钟步行距离（6 MWD）与ECOG PS评分呈中度负相关（p = 0.001，r =-0.415），BFI-疲劳对日常功能评分的影响（p = 0.013，r =-0.379）和年龄（p = 0.040，r =-0.319）。6 MWD与FACT-C评分之间存在中度正相关（p = 0.016，r = 0.369）。多元回归分析显示，只有ECOG-PS评分是显著的，并且是6 MWD的独立预测因子，解释了34.8%的方差。评估性能状态可能有一个重要的作用，以预测CRC患者的功能能力。未来的研究，包括一个更大的样本量将更清楚地阐明功能能力的预测和关系。
PurposeThe aim of this study is to determine the predictors of functional capacity and explore the relationship between functional capacity, performance status, fatigue, quality of life, anxiety, and depression in colorectal cancer (CRC) patients.MethodsForty-two patients diagnosed as stage II–III CRC according to tumor, node, metastasis (TNM) classification were included the study. Functional capacity, performance status, fatigue, quality of life, anxiety, and depression of CRC patients were assessed using six-minute walk distance (6MWD) in the six-minute walk test (6MWT), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), Brief Fatigue Inventory (BFI), Functional Assessment of Cancer Therapy-Colorectal (FACT-C), and Hospital Anxiety and Depression Scale (HADS), respectively. A multiple linear regression model was used to identify independent predictors of functional capacity.ResultsThe six-minute walk distance (6MWD) was intermediately and negatively correlated with ECOG-PS score (p = 0.001, r = −0.415), BFI-impact of fatigue on daily functioning score (p = 0.013, r = −0.379), and age (p = 0.040, r = −0.319). An intermediate and positive correlation was found between 6MWD and FACT-C score (p = 0.016, r = 0.369). The multiple regression analysis revealed that only ECOG-PS score was significant and independent predictor of the 6MWD, accounted for 34.8 % of the variance.ConclusionPerformance status was found to be the only significant predictor of functional capacity in this study. Assessing performance status may have an essential role in order to predict functional capacity in CRC patients. Future studies that include a larger sample size would more clearly elucidate the predictors and relationships of functional capacity.
影响因子：
1.9
作者：
M. Dodd;C. Miaskowski;S. Paul
通讯作者：
M. Dodd;C. Miaskowski;S. Paul