CORTICOTROPIN-RELEASING HORMONE IN AMNIOTIC-FLUID DURING GESTATION AND LABOR AND IN RELATION TO FETAL LUNG MATURATION
CORTICOTROPIN-RELEASING HORMONE IN AMNIOTIC-FLUID DURING GESTATION AND LABOR AND IN RELATION TO FETAL LUNG MATURATION
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DOI：
10.1016/s0002-9378(88)80163-7
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发表时间：
1988-10-01
影响因子：
9.8
通讯作者：
SALMINEN, KR
中科院分区：
文献类型：
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作者：
LAATIKAINEN, TJ;RAISANEN, IJ;SALMINEN, KR
在胎盘中发现了促肾上腺皮质激素释放激素，并且发现其在母体血浆中的浓度在妊娠后半期大大增加。我们研究了59例无并发症妊娠和73例并发症妊娠羊水中免疫反应性促肾上腺皮质激素释放激素的浓度。平均值（.+-.无并发症妊娠羊水中促肾上腺皮质激素释放激素的SE值在第三次妊娠中显著高于第三次妊娠（24.1 ± 0.001）。3.3 pmol/L）高于第二组（9.1 ± 0.001）。0.7 pmol/L），但在分娩过程中无变化。在胎龄匹配的组中，卵磷脂/鞘磷脂比值> 2或磷脂酰甘油试验阳性组的促肾上腺皮质激素释放激素和皮质醇平均值大于卵磷脂/鞘磷脂比值<2或磷脂酰甘油试验阴性组。在间隔1至3周采集的样本中，发现促肾上腺皮质激素释放激素和皮质醇水平伴随着磷脂酰甘油的出现而增加。羊水中促肾上腺皮质激素释放激素的浓度在糖尿病患者和先兆子痫和宫内发育迟缓的妇女中升高。我们的结论是，在最后三个月的促肾上腺皮质激素释放激素的宫内释放增加。这可能会刺激胎儿垂体肾上腺轴，促进胎儿成熟。
Corticotropin-releasing hormone was discovered in the placenta, and its concentration in the maternal plasma was found to increase greatly during the latter half of pregnancy. We studied the concentration of immunoreactive corticotropin-releasing hromone in amniotic fluid in 59 uncomplicated and in 73 complicated pregnancies. The mean (.+-.SE) value of corticotropin-releasing hromone in amniotic fluid in uncomplicated pregnancies was significantly higher in the third (24.1 .+-. 3.3 pmol/L) than in the second (9.1 .+-. 0.7 pmol/L) trimester, but no change was found during labor. In groups matched by gestational age, larger mean values of corticotropin-releasing hormone and cortisol were observed in the group in which the lecithin/sphingomyelin ratio was > 2 or the phoshatidylglycerol test was positive than in the group with a lecithin/sphingomyelin ratio < or a negative phosphatidylglycerol test result. In samples taken at an interval of 1 to 3 weeks, concomitant increases in corticotropin-releasing hormone and cortisol levels were found with the appearance of phosphatidylglycerol. Concentrations of corticotropin-releasing hormone in amniotic fluid were elevated in patients with diabetes and in women with preeclampsia and intrauterine growth retardation. We conclude that the intrauterine release of corticotropin-releasing hormone increases during the last trimester. This may stimulate the fetal pituitary-adrenal axis and promote fetal maturation.