Incidence rates of hepatitis C virus infection among blood donors in Japan: a nationwide retrospective cohort study
Incidence rates of hepatitis C virus infection among blood donors in Japan: a nationwide retrospective cohort study
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日本献血者丙型肝炎病毒感染的发病率：全国回顾性队列研究
DOI：
10.1111/trf.14951
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发表时间：
2018
期刊：
影响因子：
2.9
通讯作者：
Tanaka Junko
中科院分区：
文献类型：
--
作者：
Uchida Shigeharu;Satake Masahiro;Kurisu Akemi;Sugiyama Aya;Ko Ko;Akita Tomoyuki;Tanaka Junko
许多新的肝炎病毒感染病例被归类为显性肝炎并不能反映感染的真实发生率，因为在某些情况下，这种疾病是无症状的。本回顾性队列研究的目的是估计献血员中新发丙型肝炎病毒（HCV）感染的发生率。研究设计和方法利用2008年至2013年献血员的HCV感染病历进行5年回顾性队列研究，估计发生率。使用荧光酶免疫分析法调查HCV血清转换，然后通过核酸扩增试验确认。（95%置信区间，0.27-0.57），仅HCV RNA血清转换为7.32/10万人年（95%置信区间，6.73-7.95），如果考虑HCV RNA或抗HCV血清转换。结论本研究的HCV感染发病率低于1994-2004年的一项研究，其中HCV发病率为1.86/100，000人-年，这反映了有效的血液筛查系统和针对肝炎控制和预防的健康策略的存在。
BACKGROUNDThe classification of many new cases of hepatitis virus infection as overt hepatitis does not reflect the true incidence of infection because the disease takes an asymptomatic course in some cases. In this retrospective cohort study, we aimed to estimate the incidence rates of new hepatitis C virus (HCV) infections among the blood donors.STUDY DESIGN AND METHODA 5‐year retrospective cohort study was conducted to estimate the incidence rates by using the medical records of the blood donors between 2008 and 2013 for HCV infection. HCV seroconversions were investigated using a chemiluminescent enzyme immunoassay and then confirmed by nucleic acid amplification tests.RESULTSThe incidence rate of HCV infection was 0.40 per 100,000 person‐years (95% confidence interval, 0.27–0.57) for HCV RNA seroconversion only and 7.32 per 100,000 person‐years (95% confidence interval, 6.73–7.95) if either HCV RNA or anti‐HCV seroconversion were taken into consideration. No significant difference of new HCV infections was found between the sexes.CONCLUSIONThe incidence rate of HCV infection of this study was lower than that detected in a previous 1994–2004 study in which HCV incidence was 1.86 per 100,000 person‐year, which reflects the presence of an effective blood screening system and health strategies targeting hepatitis control and prevention.