Cells of origin of medullary projections in central gray of rat mesencephalon.
Cells of origin of medullary projections in central gray of rat mesencephalon.
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大鼠中脑中央灰质髓质投射的起源细胞。
DOI：
10.1152/jn.1980.44.5.1002
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发表时间：
1980
影响因子：
2.5
通讯作者：
Pfaff,DW
中科院分区：
文献类型：
--
作者：
Sakuma,Y;Pfaff,DW
1.电刺激麻醉雌性大鼠同侧延髓网状结构的巨细胞核和巨细胞核区，可逆向激活中脑中央灰质的74个神经元。另外8个细胞位于对侧。考虑到脊柱前凸反射（由中央灰质促进）的控制，每个细胞的特征在于其逆向反应的性质和其对动物后躯后躯的压力刺激的反应。2.逆向激活的尖峰具有1.0和25.5 ms之间的恒定延迟，平均值为10.7 +/- 0.7 ms。下行投射的起源细胞位于中央灰质和邻近中脑网状野的所有部分，除了围绕大脑导水管的中央灰质内环内。在中央灰质的腹外侧面观察到一组特别密集的细胞。在中脑导水管上方的背侧中央灰质中发现较少。4.这些细胞的自发放电率非常低，或者根本没有。脊柱前凸相关的躯体感觉刺激不能引起活动的具体变化。因此，这些细胞似乎不参与脊柱前凸行为的刺激约束反射控制。相反，它们可能参与调节下丘脑下行的影响，已知控制脊柱前凸（见参考文献48）。反过来，它们可以调节在较低水平的神经轴完成的反射弧的活动。
1. Seventy-four neurons in the central gray of the mesencephalon were antidromically activated by electrical stimulation of the gigantocellular and magnocellular nuclei region of the ipsilateral medullary reticular formation in urethan-anesthetized female rats. An additional eight cells were located contralaterally. With control of the lordosis reflex (facilitated from central gray) in mind, each cell was characterized by the properties of its antidromic response and by its response to pressure stimulation of the hindquarters of the hindquarters of the animal. 2. The antidromically activated spikes had constant latencies between 1.0 and 25.5 ms, with a mean of 10.7 +/- 0.7 ms. 3. Cells of origin of the descending projections were located in all parts of the central gray and adjacent mesencephalic reticular field except within the inner ring of the central gray that surrounds the cerebral aqueduct. A particularly dense group of cells was noted in the ventrolateral aspect of the central gray. Fewer were found in the dorsal central gray over the cerebral aqueduct. 4. These cells had very low rates of spontaneous discharge or none at all. No specific changes in activity could be elicited by lordosis-relevant somatosensory stimuli. Therefore, these cells appear not to be involved in stimulus-bound reflexive control of lordosis behavior. Instead, they may be engaged in mediating influences descending from hypothalamus, known to control lordosis (see Ref. 48). In turn, they could modulate activity in reflex arcs completed at lower levels of the neuraxis.