Involvement of HIF-1α in UVB-induced epidermal hyperplasia
Involvement of HIF-1α in UVB-induced epidermal hyperplasia
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DOI：
10.1007/s10059-009-0148-2
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发表时间：
2009-12-01
影响因子：
3.8
通讯作者：
Park, Jong-Wan
中科院分区：
文献类型：
--
作者：
Cho, Young-Suk;Kim, Chan-Hyung;Park, Jong-Wan
据信，UVB 暴露后角质形成细胞过度生长会导致皮肤光老化和癌症发展。然而，人们对表观遗传调节角质形成细胞对 UVB 反应的转录因子知之甚少。最近，HIF-1 α被发现通过控制角质形成细胞的细胞周期在表皮稳态中发挥作用，因此，我们假设HIF-1 α参与UVB诱导的角质形成细胞生长。在培养的角质形成细胞中，HIF-1 α被发现在 UVB 暴露后不久下调，并参与 UVB 诱导的增殖。在反复接受 UVB 治疗的小鼠中，表皮增生，角质形成细胞的细胞核中缺乏 HIF-1 α。基于这些结果，我们认为 HIF-1 α 的失调与 UVB 诱导的表皮增生有关。这项工作提供了对紫外线诱导光老化和皮肤癌发展的分子机制的见解。
Keratinocyte overgrowth after UVB exposure is believed to contribute to skin photoageing and cancer development. However, little is known about the transcription factors that epigenetically regulate keratinocyte response to UVB. Recently, HIF-1 alpha was found to play a role in epidermal homeostasis by controlling the keratinocyte cell cycle, and thus, we hypothesized that HIF-1 alpha is involved in UVB-induced keratinocyte growth. In cultured keratinocytes, HIF-1 alpha was found to be down-regulated shortly after UVB exposure and to be involved in UVB-induced proliferation. In mice repeatedly treated with UVB, the epidermis became hyperplasic and keratinocytes lacked HIF-1 alpha in nuclei. Based on these results, we suggest that the deregulation of HIF-1 alpha is associated with UVB-induced hyperplasia of the epidermis. This work provides insight of the molecular mechanism underlying UV-induced photoageing and skin cancer development.