RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.
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DOI：
10.1155/2012/354191
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发表时间：
2012
影响因子：
1.5
通讯作者：
Kato M
中科院分区：
文献类型：
--
作者：
Yajima I;Kumasaka MY;Thang ND;Goto Y;Takeda K;Yamanoshita O;Iida M;Ohgami N;Tamura H;Kawamoto Y;Kato M
皮肤恶性黑色素瘤是最严重的皮肤癌之一，具有高度侵袭性，对常规治疗具有显著抵抗力。黑色素瘤的发生最初是由包括紫外线（UV）在内的环境因素引发的，紫外线会诱导黑色素细胞染色体的遗传/表观遗传改变。在人类黑色素瘤中，RAS/RAF/MEK/ERK（MAPK）和PI 3 K/PTEN/AKT（AKT）信号传导途径是两种主要的信号传导途径，并且通过遗传改变而组成性激活。RAF、RAS和PTEN的突变有助于抗凋亡、异常增殖、血管生成和黑色素瘤发展和进展的侵袭。为了找到更好的治疗方法，了解这些MAPK和AKT信号转导机制的黑色素瘤的发展和进展是很重要的。在这里，我们审查MAPK和AKT信号网络与黑色素瘤的发展和进展。
Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human melanomas, the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways are two major signaling pathways and are constitutively activated through genetic alterations. Mutations of RAF, RAS, and PTEN contribute to antiapoptosis, abnormal proliferation, angiogenesis, and invasion for melanoma development and progression. To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important. Here, we review MAPK and AKT signaling networks associated with melanoma development and progression.