PLASMA-CONCENTRATIONS OF BETA-ENDORPHIN, ADRENOCORTICOTROPIC HORMONE, AND CORTISOL IN DRINKING AND ABSTINENT CHRONIC-ALCOHOLICS
PLASMA-CONCENTRATIONS OF BETA-ENDORPHIN, ADRENOCORTICOTROPIC HORMONE, AND CORTISOL IN DRINKING AND ABSTINENT CHRONIC-ALCOHOLICS
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DOI：
10.1016/0741-8329(95)00038-0
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发表时间：
1995-11-01
期刊：
影响因子：
2.3
通讯作者：
MIRANDA, MT
中科院分区：
文献类型：
--
作者：
DELARBOL, JL;AGUIRRE, JC;MIRANDA, MT
先前关于内源性阿片系统和饮酒之间关系的研究报告了相互矛盾的结果。为了阐明这种联系，我们比较了70名戒酒者和80名对照者在不同戒酒时间后的血浆β-内啡肽、促肾上腺皮质激素和皮质醇浓度。酗酒者的血浆β-内啡肽降低（18.61 +/- 1.38 vs. 39.31 +/- 3.44 pg/ml），即使戒酒超过10年。这种效应可能是由四氢异喹啉系统介导的，因此可能是由长期饮酒引起的。另一方面，β-内啡肽循环浓度的降低可能是酗酒的原因，而不是结果。酗酒者和对照者的促肾上腺皮质激素和皮质醇血浆水平没有差异（ACTH为19.29 +/- 1.66 vs. 13.27 +/- 1.85 pg/ml，皮质醇为20.37 +/- 0.78 vs. 17.22 +/- 0.64 ng/ml），因此似乎与慢性饮酒无关。
Previous studies of the relationship between the endogenous opioid system and alcohol consumption have reported contradictory results. To shed light on this connection, we compared plasma concentrations of beta-endorphin, adrenocorticotropic hormone, and cortisol in 70 alcoholic persons after different periods of abstinence and a group of 80 control subjects. Plasma beta-endorphin was decreased in alcoholics (18.61 +/- 1.38 vs. 39.31 +/- 3.44 pg/ml), even after more than 10 years' abstinence. This effect may be mediated by the tetrahydroisoquinoline system, and may thus result from chronic alcohol consumption. On the other hand, lowered circulating concentrations of beta-endorphin may be a cause, rather than an effect, of alcoholism. Plasma levels of adrenocorticotropic hormone and cortisol did not differ in alcoholics and controls (19.29 +/- 1.66 vs. 13.27 +/- 1.85 pg/ml for ACTH, 20.37 +/- 0.78 vs. 17.22 +/- 0.64 ng/ml for cortisol), and thus appear to have no relation with chronic alcohol consumption.