Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase
Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase
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DOI：
10.1128/jvi.01496-09
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发表时间：
2010-02-15
影响因子：
5.4
通讯作者：
Estaquier, Jerome
中科院分区：
文献类型：
--
作者：
Campillo-Gimenez, Laure;Laforge, Mireille;Estaquier, Jerome
在灵长类动物模型中，发散型Toll样受体7(TLR7)和TLR9信号被用来区分致病性和非致病性猴免疫缺陷病毒感染。我们在这里证明，与非致病的非洲绿猴相比，致病恒河猴中I型干扰素的表达增加与淋巴结浆细胞样树突状细胞的招募和感染后早期炎症环境的存在有关，而不是TLR7/9反应的差异。
Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.