Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
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DOI：
10.1017/s1355617708080302
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发表时间：
2008-03-01
影响因子：
2.6
通讯作者：
Kawas, Claudia
中科院分区：
文献类型：
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作者：
Grober, Ellen;Hall, Charles B.;Kawas, Claudia
在巴尔的摩老龄化纵向研究（BLSA）中，我们通过情景记忆测试（自由回忆油自由和提示选择性提醒测试）检查了表现下降的时间展开。对 92 名患有阿尔茨海默病 (AD) 的受试者进行了长达 15 年的痴呆诊断前执行功能（类别流利度、字母流利度和轨迹）和言语智力（Nelson。1982 年：美国版尼尔森成人阅读测试 [AMNART]）的测试。为了检查认知能力下降的临床前发生情况，我们在 AD 最初诊断时对受试者进行了排列，并检查了诊断前的认知过程。我们发现情景记忆的性能油测试在诊断前 7 年加速下降。执行功能的性能油测试在诊断前 2-3 年加速下降。语言智力在接近诊断时下降。这种认知特征与病理数据相一致，表明在 AD 临床前 P 发作期间，介导记忆的结构比额叶结构更早受到影响。它还支持 AMNART 估计的 VIQ 在 AD 临床前发病期间不会下降的观点。
In the Baltimore Longitudinal Study of Aging (BLSA), we examined the temporal unfolding of declining performance on tests of episodic memory (Free Recall oil the Free and Cued Selective Reminding Test). executive function (Category Fluency, Letter Fluency, and Trails), and Verbal Intelligence (Nelson. 1982: American Version of the Nelson Adult Reading Test [AMNART]) before the diagnosis of dementia in 92 Subjects with incident Alzheimer's disease (AD) followed for up to 15 years before diagnosis. To examine the preclinical onset of cognitive decline, we aligned subjects at the little of initial AD diagnosis and examined the cognitive Course preceding diagnosis. We found that declines in performance oil tests of episodic memory accelerated 7 years before diagnosis. Declining performance oil tests of executive function accelerated 2-3 years before diagnosis. and verbal intelligence declined in close proximity to diagnosis. This cognitive profile is compatible with pathologic data suggesting that Structures which mediate memory are affected earlier than frontal structures during, the preclinical P onset of AD. It also Supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD.