Advanced MRI Protocols to Discriminate Glioma From Treatment Effects: State of the Art and Future Directions.
Advanced MRI Protocols to Discriminate Glioma From Treatment Effects: State of the Art and Future Directions.
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DOI：
10.3389/fradi.2022.809373
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hu, Leland S.
中科院分区：
文献类型：
--
作者：
Malik, Dania G.;Rath, Tanya J.;Acevedo, Javier C. Urcuyo;Canoll, Peter D.;Swanson, Kristin R.;Boxerman, Jerrold L.;Quarles, C. Chad;Schmainda, Kathleen M.;Burns, Terry C.;Hu, Leland S.
在高级别胶质瘤（HGGs）的随访治疗中，区分真正的肿瘤进展与治疗相关的影响，如假进展和放射性坏死，是一个持续的临床挑战。常规MRI伴或不伴静脉造影剂可作为HGG治疗后监测影像学的临床基准。然而，许多先进的成像技术已经显示出在帮助更好地描述不确定情况下的发现的希望，因为常规成像的治疗后效果通常可以模拟真实的肿瘤进展。这些挑战被通常发生在肿瘤生长和治疗后床内治疗相关效应之间的组织学混合物进一步混淆。本文综述了目前HGG监测成像的实践以及先进成像技术的作用，包括灌注MRI和代谢MRI。
In the follow-up treatment of high-grade gliomas (HGGs), differentiating true tumor progression from treatment-related effects, such as pseudoprogression and radiation necrosis, presents an ongoing clinical challenge. Conventional MRI with and without intravenous contrast serves as the clinical benchmark for the posttreatment surveillance imaging of HGG. However, many advanced imaging techniques have shown promise in helping better delineate the findings in indeterminate scenarios, as posttreatment effects can often mimic true tumor progression on conventional imaging. These challenges are further confounded by the histologic admixture that can commonly occur between tumor growth and treatment-related effects within the posttreatment bed. This review discusses the current practices in the surveillance imaging of HGG and the role of advanced imaging techniques, including perfusion MRI and metabolic MRI.
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