FUSION OF THE LEUCINE ZIPPER GENE HLF TO THE E2A GENE IN HUMAN ACUTE B-LINEAGE LEUKEMIA
FUSION OF THE LEUCINE ZIPPER GENE HLF TO THE E2A GENE IN HUMAN ACUTE B-LINEAGE LEUKEMIA
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DOI：
10.1126/science.1386162
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发表时间：
1992-07-24
期刊：
影响因子：
56.9
通讯作者：
LOOK, AT
中科院分区：
文献类型：
--
作者：
INABA, T;ROBERTS, WM;LOOK, AT
A t（17; 10）早期B系急性白血病中的染色体易位显示产生嵌合转录物，其含有来自染色体19上的E2 A碱性螺旋-环-螺旋转录因子基因的序列，与来自染色体17上编码肝白血病因子的先前未鉴定的基因（HLF）的序列融合。嵌合蛋白由E2 A的氨基端反式激活结构域连接到HLF的羧基端碱性区-亮氨酸拉链结构域组成。HLF通常在肝脏和肾脏中表达，但在淋巴细胞中不表达，并且被发现与调节发育阶段特异性基因表达的含亮氨酸拉链的转录因子DBP（白蛋白D-box结合蛋白）和TEF（促甲状腺细胞胚胎因子）密切相关。
A t(17;10) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.