3D bioprinting of triphasic nanocomposite hydrogels and scaffolds for cell adhesion and migration
3D bioprinting of triphasic nanocomposite hydrogels and scaffolds for cell adhesion and migration
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DOI：
10.1088/1758-5090/ab15ca
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发表时间：
2019-07-01
期刊：
影响因子：
9
通讯作者：
Kehr, Nermin S.
中科院分区：
文献类型：
--
作者：
Motealleh, Andisheh;Dorri, Pooya;Kehr, Nermin S.
在这项研究中，我们描述了3D生物打印的三相手性纳米复合材料（NC）水凝胶/支架的第一个例子，以模拟复杂的3D架构，纳米/微米尺度的形貌和细胞外基质的手性性质。这些多功能构建体是使用3D生物打印技术制备的，由三个连接的水凝胶/支架组成，其中两个载有用生物分子的对映异构体官能化的纳米材料。利用这些构建体，我们引导细胞向含有细胞优选的生物分子对映体的三相手性NC水凝胶/支架的部分迁移。
In this study we describe the first example of 3D bioprinted triphasic chiral nanocomposite (NC) hydrogels/scaffolds to simulate the complex 3D architecture, nano/micro scale topography, and chiral nature of extracellular matrix. These multifunctional constructs are prepared using a 3D bioprinting technique and are composed of three connected hydrogels/scaffolds, two of which are loaded with nanomaterials functionalized with opposite enantiomers of a biomolecule. With these constructs, we direct the migration of cells toward the part of the triphasic chiral NC hydrogels/scaffolds containing the cells' preferred biomolecule enantiomer.