Different norovirus genotypes in patients with gastroenteritis in Kuwait
Different norovirus genotypes in patients with gastroenteritis in Kuwait
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DOI：
10.1002/jmv.23645
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发表时间：
2013-09-01
影响因子：
12.7
通讯作者：
Albert, M. John
中科院分区：
文献类型：
--
作者：
Al-Rashidi, Amirah;Chehadeh, Wassim;Albert, M. John
诺如病毒是全世界急性胃肠炎的主要病因。这种病毒感染在科威特的重要性尚不清楚。通过RT-PCR， 2006-2007年期间在一家医院研究的100个5岁以下肠胃炎儿童粪便样本中有8个（8.0%），2010-2011年期间在另一家医院研究的70个类似儿童粪便样本中有6个（8.5%）诺如病毒呈阳性。在这两家医院研究的170个样本中，10个样本经ELISA检测呈诺如病毒阳性。诺如病毒株系统进化树分析显示，50%的诺如病毒株属于GII.4基因型，优势株为GII.4 2006b。其他检测到的基因型有GII.12、GII。b、GII.3、GII.8、GII.7。这项研究强调了在急性胃肠炎中筛查诺如病毒感染的重要性，并建立了一个报告系统，以更好地了解科威特诺如病毒感染的流行病学。中华检验医学杂志，35(5):611- 618,2013。(c) 2013 Wiley Periodicals, Inc.；
Norovirus is a leading cause of acute gastroenteritis worldwide. The importance of this virus infection in Kuwait is not known. Eight out of 100 stool samples (8.0%) from children up to 5 years of age with gastroenteritis studied during 2006-2007 from one hospital, and 6 out of 70 stool samples (8.5%) from similar children studied from another hospital during 2010-2011 were positive for norovirus by RT-PCR. Out of these 170 samples studied from both hospitals, 10 samples were positive for norovirus when tested by ELISA. Phylogenetic tree analysis of norovirus strains showed that 50% of the norovirus strains belonged to genotype GII.4, and the predominant strain was GII.4 2006b. Other detected genotypes were GII.12, GII.b, GII.3, GII.8, and GII.7. This study highlights the importance of screening for norovirus infection in acute gastroenteritis and having a reporting system to understand better the epidemiology of norovirus infection in Kuwait. J. Med. Virol. 85:1611-1618, 2013. (c) 2013 Wiley Periodicals, Inc.