Age-Associated Changes in the Retinal Nerve Fiber Layer and Optic Nerve Head
Age-Associated Changes in the Retinal Nerve Fiber Layer and Optic Nerve Head
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DOI：
10.1167/iovs.14-14303
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发表时间：
2014-08-01
影响因子：
4.4
通讯作者：
Harwerth, Ronald S.
中科院分区：
文献类型：
--
作者：
Patel, Nimesh B.;Lim, Mimi;Harwerth, Ronald S.
目的.视网膜神经纤维层（RNFL）厚度和神经视网膜边缘（NRR）参数的光学相干断层扫描（OCT）测量通常用作视网膜神经节细胞含量的替代。本研究的目的是调查这些形态学措施和老化对这些结构的影响之间的关系。招募了113名健康个体，年龄在19至76岁之间，先前没有视网膜或视神经乳头病变史。以视神经乳头（ONH）为中心的视乳头周围和径向OCT扫描用于数据分析。使用光学生物测量法计算每个受试者的横向比例。自定义算法用于ONH NRR和RNFL的形态学分析，包括主要视网膜血管贡献的量化。有一个显着的年龄相关性损失的RNFL厚度（-0.23 μ m/y，R-2 = 0.24，P < 0.01），主要视网膜血管贡献（-0.03 μ m/y，R-2 = 0.07，P = 0.01）、神经环体积（NRV，-0.004 mm（3）/y，R-2 = 0.15，P < 0.01）和最小边缘宽度（MRW，-1.77 μ m/y，R-2 = 0.23，P < 0.01）在加入Bruch膜开口尺寸（sMRW，-1.86 μ m/y，R-2 = 0.22，P < 0.01）之前和之后。归一化后ONH NRR参数的变化率（NRV，0.69%/y和sMRW，0.50%/y）大于RNFL厚度（0.19%/y，P < 0.01）。虽然RNFL和ONH NRR参数都包含视网膜神经节细胞的轴突，但这些指标的年龄相关变化存在差异，在临床应用中应予以考虑。
PURPOSE. Optical coherence tomography (OCT) measures of the retinal nerve fiber layer (RNFL) thickness and neuroretinal rim (NRR) parameters are often used as a surrogate for retinal ganglion cell content. The purpose of this study was to investigate the relationship between these morphological measures and the aging effects on these structures.METHODS. One hundred thirteen healthy individuals, aged 19 to 76 years, with no prior history of retinal of optic nerve head pathology were recruited. A circumpapillary and radial OCT scan centered on the optic nerve head (ONH) was used for data analysis. Transverse scaling was calculated for each subject using measures from optical biometry. Custom algorithms were used for morphological analysis of the ONH NRR and RNFL that included quantification of major retinal vascular contribution.RESULTS. There was a significant age-related loss of RNFL thickness (-0.23 mu m/y, R-2 = 0.24, P < 0.01), major retinal vascular contribution (-0.03 mu m/y, R-2 = 0.07, P = 0.01, neural rim volume (NRV, -0.004 mm(3)/y, R-2 = 0.15, P < 0.01), and minimum rim width (MRW, -1.77 mu m/y, R-2 = 0.23, P < 0.01) before, and after, incorporating the Bruch's membrane opening size (sMRW, -1.86 mu m/y, R-2 = 0.22, P < 0.01). When normalized, the rates of change for ONH NRR parameters (NRV, 0.69%/y and sMRW, 0.50%/y) exceeded that of RNFL thickness (0.19%/y, P < 0.01).CONCLUSIONS. Although both RNFL and ONH NRR parameters contain axons of retinal ganglion cells, there are differences in age-related changes in these measures that should be considered in clinical application.