Analysis of Biological Apatite Crystal Orientation in Anterior Cortical Bone of Human Mandible Using Microbeam X-ray Diffractometry
Analysis of Biological Apatite Crystal Orientation in Anterior Cortical Bone of Human Mandible Using Microbeam X-ray Diffractometry
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DOI：
10.2320/matertrans.m2011329
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发表时间：
2012-05-01
影响因子：
1.2
通讯作者：
Abe, Shinichi
中科院分区：
文献类型：
--
作者：
Furuya, Hidetaka;Matsunaga, Satoru;Abe, Shinichi
人类的下颌是一种独特的骨骼，有利于咀嚼。颌的结构特性由通过牙齿传递的机械应力决定。然而，评估这些机械应力对骨骼的影响非常困难。近年来，人们已经清楚生物磷灰石（BAp）晶体的取向与局部应力密切相关，并且被认为比骨矿物质密度（BMD）对局部应力的反应更敏锐。对于具有复杂咀嚼功能的人类下颌机械应力响应的 BAP 晶体排列的研究很少。本研究的目的是利用微型计算机断层扫描 (micro-CT) 和微束 X 射线衍射法定量评估人下颌骨前皮质骨的 BMD 和 BAp 晶体取向。比较牙槽区域和下颌基部的机械应力的强度和方向。将日本骨样本中的下颌中切牙区域指定为感兴趣区域，并测量牙槽区域和下颌基部的BMD和BAp晶体取向。通过显微 CT 对骨样本进行成像，并将获得的数据转换为 BMD 值。 BAP 晶体取向通过基于反射和透射的微束 X 射线衍射法测定。使用(002)和(310)的X射线衍射峰计算衍射强度比。结果显示各区域的BM D值没有差异。 BAP 晶体主要沿下颌基部的近远中方向取向，在牙槽区域沿咀嚼力方向取向。这些发现表明，下颌基部表现出长骨样特征，下颌髁突充当骨的头部，而在牙槽区域中，对齐发生在通过牙齿施加的机械应力产生的咀嚼力的方向上。定性评估揭示了下颌基底部和牙槽区域之间的明显差异，表明 BAp 晶体取向比 BMD 提供了更精确的骨质量指标。 [doi:10.2320/matertrans.M2011329]
The human jaw is a unique bone that facilitates mastication. The structural properties of the jaw are determined by mechanical stresses transmitted via the teeth. However, it is very difficult to evaluate the impact of these mechanical stresses on bone. In recent years, it has become clear that the orientation of biological apatite (BAp) crystals is closely related to local stress, and is thought to respond more acutely to local stress than bone mineral density (BMD). Few studies have been conducted on BAp crystal alignment in response to mechanical stress in the human jaw, which has a complex masticatory function. The purpose of this study was to quantitatively evaluate BMD and BAp crystal orientation using micro-computed tomography (micro-CT) and microbeam X-ray diffractometry in the anterior cortical bone of human mandible. The intensity and direction of mechanical stresses in both the alveolar area and mandibular base were compared.The mandibular central incisor region in Japanese bone samples was designated as the region of interest and BMD and BAp crystal orientation in the alveolar area and mandibular base measured. Bone samples were imaged by micro-CT and the data obtained converted into BMD values. BAp crystal orientation was determined by both reflection- and transmission-based microbeam X-ray diffractometry. The diffraction intensity ratio was calculated using X-ray diffraction peaks of (002) and (310).The results showed no difference in BM D values among regions. BAp crystals were oriented predominantly in the mesiodistal direction in the mandibular base and along the direction of masticatory force in the alveolar area. These findings suggest that the mandibular base exhibits long bone-like characteristics, with the mandibular condyle acting as the head of the bone, while in the alveolar area alignment takes place in the direction of masticatory force resulting from mechanical stress exerted via the teeth. Qualitative evaluation revealed clear differences between the mandibular base and alveolar area, suggesting that BAp crystal orientation offers a more precise indicator of bone quality than BMD. [doi:10.2320/matertrans.M2011329]