Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats
Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats
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DOI：
10.1097/00005344-200307000-00004
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发表时间：
2003-07-01
影响因子：
3
通讯作者：
Berthelot, A
中科院分区：
文献类型：
--
作者：
Berthon, N;Laurant, P;Berthelot, A
本研究的目的是调查是否在DOCA盐高血压大鼠的饮食镁补充诱导的血压降低与内皮素-1的表达和组织生产的修改。DOCA-盐处理增加血压，诱导肾脏和心脏肥大，并增加肾脏、心脏和主动脉中内皮素-1的表达和产生。镁补充8周降低DOCA盐高血压大鼠的血压，并防止心脏，主动脉和肾脏中的肥大和内皮素-1表达和产生的增加。用ETA受体拮抗剂ABT-627治疗，以阐明镁补充剂对血压的降低作用与内皮素-1产生之间的关系。当DOCA盐大鼠用ABT-627治疗8周时，镁补充剂未能降低血压。总之，这些研究结果表明，镁补充剂对血压的降低作用需要对DOCA盐高血压大鼠中内皮素-1活性和/或内皮素-1产生的抑制作用。
The aim of this study was to investigate whether or not the decrease in blood pressure induced by dietary magnesium supplementation in DOCA-salt hypertensive rats is associated with modifications in expression and tissular production of endothelin-1. DOCA-salt treatment increased blood pressure, induced renal and cardiac hypertrophy, and increased endothelin-1 expression and production in the kidney, heart, and aorta. Mg supplementation for 8 weeks lowered blood pressure in DOCA-salt hypertensive rats and prevented hypertrophies and the increase of endothelin-1 expression and production in the heart, aorta, and kidney. Treatment with a receptor ETA antagonist, ABT-627, was used to clarify the relationship between the lowering effect of Mg supplementation on blood pressure and endothelin-1 production. When DOCA-salt rats were treated with ABT-627 for 8 weeks, Mg supplementation failed to lower blood pressure. In conclusion, these findings suggest that the lowering effect of Mg supplementation on blood pressure requires an inhibitory effect on endothelin-1 activity and/or endothelin-1 production in DOCA-salt hypertensive rats.