Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections
Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections
复制标题
DOI：
10.1128/jvi.77.2.1571-1577.2003
复制
发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Diallo, A
中科院分区：
文献类型：
--
作者：
Berhe, G;Minet, C;Diallo, A
构建了含有小反刍兽疫病毒（PPRV）融合蛋白基因cDNA的重组羊痘病毒疫苗。采用快速有效的方法来选择高度纯化的重组病毒克隆。一项试验表明，低至 0.1 PFU 的剂量的这种重组体可以保护山羊免受 PPRV 毒株的攻击。
A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.