Linear IgA disease and oesophageal carcinoma
Linear IgA disease and oesophageal carcinoma
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线性 IgA 疾病与食管癌
DOI：
10.1177/014107688708000118
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发表时间：
1987
影响因子：
17.3
通讯作者：
S. Natarajan
中科院分区：
文献类型：
--
作者：
S. Green;S. Natarajan
线性 IgA 疾病是一种皮肤大疱性疾病，尽管罕见，但引起了相当多的讨论！”3. 大多数权威机构将其视为疱疹样皮炎 (DH) 的一种变体，尽管一些工作人员将其视为类天疱疮的一种形式”。然而，与经典 DH 一样，它确实对氨苯砜有反应。至少自 1909 年以来，已知皮肤大疱性疾病（例如经典 DH）有时与发生内部恶性疾病的风险增加有关。一项主要研究调查了 DH 患者恶性肿瘤的发病率，其中遇到了少数线性 IgA 疾病病例（总共 8 例），初步结果支持了这样的假设：与经典 DH 的情况一样，线性 IgA 疾病患者发生恶性瘤的风险可能增加。肿瘤性病变”，现已报道一例患者在确诊线性 IgA 疾病 15 个月后出现食管鳞状细胞癌。
Linear IgA disease is a cutaneous bullous condition that, despite its rarity, has provoked considerable discussion!" 3. Most authorities regard it as a variant of dermatitis herpetiformis (DH), although some workers have viewed it as a form of pemphigoid". Like classical DH, however, it does respond to dapsone. Since at least 1909,cutaneous bullous disorders (such as classical DH) have been known to be associated on occasions with an increased risk of developing internal malignant disease". Preliminary results from a major study that investigated the incidence of malignant neoplasia in DH sufferers, and in which a small number of cases oflinear IgA disease (8 in total) were encountered, lent support to the hypothesis that, as is the situation with classical DH, patients with linear IgA disease may have an increased risk of developing neoplastic Iesions", A case is now reported in which a patient developed squamous carcinoma of the oesophagus 15 months after a diagnosis of linear IgA disease had been established.