Damage to the insula disrupts addiction to cigarette smoking
Damage to the insula disrupts addiction to cigarette smoking
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DOI：
10.1126/science.1135926
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发表时间：
2007-01-26
期刊：
影响因子：
56.9
通讯作者：
Bechara, Antoine
中科院分区：
文献类型：
--
作者：
Naqvi, Nasir H.;Rudrauf, David;Bechara, Antoine
许多大脑系统都与成瘾行为有关，但没有一个被证明是维持吸烟成瘾所必需的。我们发现，与脑岛无关的脑损伤吸烟者相比，脑岛受损的吸烟者更有可能经历吸烟成瘾的中断，其特点是能够轻松、立即戒烟，不会复发，也不会持续吸烟的冲动。这一结果表明，脑岛是吸烟成瘾的关键神经基质。
A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking.