The threshold vs LNT showdown: Dose rate findings exposed flaws in the LNT model part 2. How a mistake led BEIR I to adopt LNT
The threshold vs LNT showdown: Dose rate findings exposed flaws in the LNT model part 2. How a mistake led BEIR I to adopt LNT
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DOI：
10.1016/j.envres.2016.11.024
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发表时间：
2017-04-01
影响因子：
8.3
通讯作者：
Calabrese, Edward J.
中科院分区：
文献类型：
--
作者：
Calabrese, Edward J.
本文揭示了在美国国家科学院（NAS）电离辐射生物效应（BEIR）I委员会（1972）使用Russell的剂量率数据支持采用线性无阈值（LNT）剂量反应模型进行遗传和癌症风险评估近25年后，Russell承认历史对照组的突变率显著低报。这一错误是BEIR I所不知道的，具有深远的影响，导致它错误地采用了LNT模型，这一决定深刻地改变了迄今为止辐射和化学品风险评估的进程。
This paper reveals that nearly 25 years after the National Academy of Sciences (NAS), Biological Effects of Ionizing Radiation (BEIR) I Committee (1972) used Russell's dose-rate data to support the adoption of the linear-no-threshold (LNT) dose response model for genetic and cancer risk assessment, Russell acknowledged a significant under-reporting of the mutation rate of the historical control group. This error, which was unknown to BEIR I, had profound implications, leading it to incorrectly adopt the LNT model, which was a decision that profoundly changed the course of risk assessment for radiation and chemicals to the present.