Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat.
Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat.
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一氧化氮衍生的氧化剂在大鼠一氧化碳血管损伤中的作用。
DOI：
10.1152/ajpheart.1999.276.3.h984
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ischiropoulos,H
中科院分区：
文献类型：
--
作者：
Thom,SR;Fisher,D;Xu,YA;Garner,S;Ischiropoulos,H
Studies were conducted with rats to investigate whether exposure to CO at concentrations frequently found in the environment caused nitric oxide (NO)-mediated vessel wall changes. Exposure to CO at concentrations of 50 parts per million or higher for 1 h increased the concentration of nitrotyrosine in the aorta. Immunologically reactive nitrotyrosine was localized in a discrete fashion along the endothelial lining, and this was inhibited by pretreatment with the NO synthase (NOS) inhibitorNω-nitro-l-arginine methyl ester (l-NAME). The CO-induced elevations of aortic nitrotyrosine were not altered by neutropenia or thrombocytopenia, and CO caused no change in the concentration of endothelial NOS. Consequences from NO-derived stress on the vasculature included an enhanced transcapillary efflux of albumin within the first 3 h after CO exposure and leukocyte sequestration that became apparent 18 h after CO exposure. Oxidized plasma low-density lipoprotein was found immediately after CO exposure, but this was not inhibited byl-NAME pretreatment. We conclude that exposure to relatively low CO concentrations can alter vascular status by several mechanisms and that many changes are linked to NO-derived oxidants.
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高胆固醇血症对动脉粥样硬化易感性不同的两个物种的组织抗氧化状态的影响。
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
Godin Dv;D. Dm
通讯作者：
D. Dm
吸入烟雾并发全身应激会导致肺泡损伤。
DOI：
10.1164/ajrccm.149.1.8111586
发表时间：
1994
影响因子：
24.7
作者：
Thom,SR;Mendiguren,I;VanWinkle,T;Fisher,D;Fisher,AB
通讯作者：
Fisher,AB
一氧化碳：社区空气污染与死亡率的关联
影响因子：
56.9
作者：
A. Hexter;J. Goldsmith
通讯作者：
J. Goldsmith
影响因子：
3.9
作者：
ISCHIROPOULOS, H;ZHU, L;BECKMAN, JS
通讯作者：
BECKMAN, JS
大鼠长期暴露于一氧化碳期间的心动力变化。
影响因子：
3.8
作者：
D. Penney;P. Sodt;A. Cutilletta
通讯作者：
A. Cutilletta