Multifunctional magnetic co-delivery system coated with polymer mPEG-PLL-FA for nasopharyngeal cancer targeted therapy and MR imaging
Multifunctional magnetic co-delivery system coated with polymer mPEG-PLL-FA for nasopharyngeal cancer targeted therapy and MR imaging
复制标题
聚合物mPEG-PLL-FA涂层多功能磁力共递送系统用于鼻咽癌靶向治疗和MR成像
DOI：
10.1177/0885328217692964
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发表时间：
2017-03-01
影响因子：
2.9
通讯作者：
Xie, Minqiang
中科院分区：
文献类型：
--
作者：
Li, Hailiang;Fu, Chaoping;Xie, Minqiang
基因和药物共递送系统已成为战胜癌症的主要策略之一。本文设计了一种多功能磁共释放系统，用于鼻咽癌靶向治疗和磁共振成像。以海藻酸钠（阿萨）修饰氧化铁，通过配位键负载顺铂，形成核心配合物。以聚赖氨酸-甲氧基-聚乙二醇-叶酸为壳层，通过电相互作用包覆核心复合物，使纳米药物具有靶向性。该聚合物还可以赋予纳米药物粘附和保护DNA的能力，并提高其在水中的溶解度。将该纳米药物转染HNE-1细胞后，含抑癌基因TFPI 2的质粒可进入HNE-1细胞并表达。它与顺铂有协同作用，可引起较高的死亡率和凋亡率，抑制鼻咽癌细胞的迁移和克隆形成。此外，该纳米药物在T2 MR成像下可获得清晰的图像。这种磁性共递送系统显示出作为一种强大的多功能载体的潜力，用于药物递送和基因载体在鼻咽癌中的应用。
The gene and drug co-delivery system has become one of the primary strategies to overcome cancers. Here, we designed a multifunctional magnetic co-delivery system for nasopharyngeal carcinoma-targeted therapy and MR imaging. Aldehyde sodium alginate (ASA) was used to decorate the oxide iron and load cisplain through coordinate bond to form a core complex. The polymer shell poly(l-lysine)-methoxy-polyethylene glycol-folate was used to coat the core complex through electric interaction to give this nano-medicine a target ability. And this polymer could also give the nano-medicine abilities to adhere and protect DNA, and enhance its solubleness in water. After being transfected with this nano-medicine, the plasmids which contain cancer suppressor gene TFPI2 could enter and express in HNE-1 cells. It caused a higher death and apoptosis rate, inhibited nasopharyngeal carcinoma cells’ migration and cloning by the synergic effect together with cisplain. Besides, clear images of this nano-medicine could be got under T2 MR imaging. This magnetic co-delivery system demonstrates a potential as a powerful multifunctional vector for drug delivery and gene vector applications in nasopharyngeal carcinoma.