THE PATHOGENESIS OF NATURAL AND SIMULATED NATURAL FOOT-AND-MOUTH-DISEASE INFECTION IN CATTLE
THE PATHOGENESIS OF NATURAL AND SIMULATED NATURAL FOOT-AND-MOUTH-DISEASE INFECTION IN CATTLE
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DOI：
10.1016/0021-9975(81)90089-x
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发表时间：
1981-01-01
影响因子：
0.8
通讯作者：
GOODRIDGE, D
中科院分区：
文献类型：
--
作者：
BURROWS, R;MANN, JA;GOODRIDGE, D
通过从咽部连续取样和屠宰后的组织滴定，确定了通过各种途径暴露于口蹄疫病毒的牛中病毒的早期（病毒血症前）定位和增殖部位。在检测到病毒血症之前，从37头牛中的30头牛的咽部回收病毒，这些牛通过直接或间接接触或暴露于病毒气溶胶> 1天。在病毒血症发作前杀死的23头牛的组织中病毒的分布和数量表明，咽部区域是最可能的初始感染和病毒生长的部位。
The sites of early (pre-viremic) localization and multiplication of virus in cattle exposed to foot-and-mouth disease virus by various routes were identified by sequential sampling from the pharynx and by tissue titrations after slaughter. Virus was recovered from the pharynx of 30 of 37 cattle exposed by direct or indirect contact or to virus aerosols for > 1 days before the detection of viremia. The distribution and amounts of virus in the tissues of 23 cattle killed before the onset of viremia indicated that the pharyngeal area was the most likely site of initial infection and virus growth.