ACTIVITY-DEPENDENT K+ ACCUMULATION IN THE DEVELOPING RAT OPTIC-NERVE
ACTIVITY-DEPENDENT K+ ACCUMULATION IN THE DEVELOPING RAT OPTIC-NERVE
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DOI：
10.1126/science.7079771
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
GUTNICK, MJ
中科院分区：
文献类型：
--
作者：
CONNORS, BW;RANSOM, BR;GUTNICK, MJ
用K+敏感微电极研究了不同日龄（1 d至成年）大鼠视神经细胞外K+浓度（[K+]0）的活动依赖性变化。最大水平，[K+]0上升与最佳频率的刺激取决于年龄：平均最大诱发[K+]0是17.2 mM的1-3天的年龄视神经和9.8 mM的成人神经。在未成熟视神经中观察到的天花板[K+]0对于哺乳动物CNS结构来说是独特的大，这可能是由于诱发K+释放的相对增强的速率。
K+-sensitive microelectrodes were used to study activity-dependent changes of extracellular K+ concentration ([K+]0) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]0 rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+]0 was 17.2 mM in 1-3 day old optic nerves and 9.8 mM in adult nerves. The ceiling [K+]0 seen in immature optic nerves, which is uniquely large for a mammalian CNS structure, may result from a relatively enhanced rate of evoked K+ release.