Modification of distribution of gallium 67 in man by administration of iron.
Modification of distribution of gallium 67 in man by administration of iron.
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通过施用铁改变人体中镓 67 的分布。
DOI：
10.1259/0007-1285-53-630-572
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Martin
中科院分区：
文献类型：
--
作者：
R. Sephton;J. Martin
在荷瘤小鼠中，如果血清不饱和铁结合能力（UIBC）较低，则67Ga从血液中清除和达到高肿瘤与正常软组织浓度比的速度加快。初步临床试验描述，有关铁的管理作为一种手段，创造有利的成像分布注射67Ga后6小时内。根据患者的UIBC，肌注铁的剂量在50- 100mg范围内，一般在67Ga后3小时。在14例接受铁治疗的患者中，67Ga血浆浓度和UIBC均出现持续且显著的降低。在其中的7例中，6h 67Ga图像显示病变的对比几乎等同于稍后（48小时）图像的对比：另外2例病变直到48小时才被检测到。6小时的结果相对没有肠道外观，有时会混淆后来的研究，检查通常受益于6小时获得的提前信息。
In mice bearing tumours, the clearance of 67Ga from blood and the attainment of high tumour-to-normal soft-tissue concentration ratios are accelerated if the serum unsaturated iron-binding capacity (UIBC) is low. A preliminary clinical trial is described, concerning the administration of iron as a means of creating favourable imaging distributions within 6 h of injection of 67Ga. Iron was given intramuscularly at a dosage in the range 50-100 mg, depending on the patient's UIBC and generally about 3 h post 67Ga. In 14 patients receiving iron, consistent and substantial reductions in 67Ga plasma concentrations and in UIBC were demonstrated. In seven of these, the 6 h 67Ga images revealed lesions at contrasts which were nearly equivalent to their contrasts in later (48 h) pictures: there were an additional two cases where the lesion was not detected until 48 h. The 6 h results were relatively free of the bowel appearances which sometimes confuse later studies, and examinations generally benefited from the advance information gained at 6 h.